YProTech High Potency Chemistry Services


YProtech is a leading UK Chemistry CRO providing specialist chemistry services, including the synthesis of high potency compounds for Antibody Drug Conjugates (ADCs).


The YProtech Advantage

Bespoke synthesis of HPAPIs
Specialist UK based High Potency Facility including:
Customer Focused
  • Expertise in the synthesis of HP small molecules offering upstream synthesis of cytotoxins for the ADC market
  • Combination of toxin-linker for development of novel payloads
  • Capability and expertise to synthesise compounds on up to small gram scale to support pre clinical research and development
  • All chemistry staff PhD level organic chemists
  • Selection of products available from stock, both toxins (e.g. Duocarmycins, PBDs) and linkers (e.g. cleavable peptide derivatives such as Boc-Val-Ala-PAB-PNP)
  • Clean room with isolator independently tested and operates at OEL < 1ng.m3 as an 8 hour time weighted average (TWA) allowing containment of most potent HPAPIs
  • Separate wet chemistry lab dedicated to high potency synthesis
  • Air handling system that operates under negative pressure cascade
  • Detailed safety protocols, standard operating procedures and full risk assessments carried out
  • Fully trained staff
  • Analytical capabilities include 500 MHz NMR and LCMS
  • Customer confidentiality and IP protection guaranteed
  • Customers include technology developers for toxins, linkers, antibodies and ADCs
  • Single point of contact and clear customer communication and project updates to ensure all information is shared to allow project decisions to be taken efficiently
  • Bespoke solutions to our customers’ research project challenges through flexible project execution

Please complete the contact form to receive additional information or book a call from one of our technical experts.

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